Extracellular ATP Stimulates NO Production in Rat Thick Ascending Limb

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Extracellular ATP stimulates NO production in rat thick ascending limb.

NO produced by NO synthase (NOS) 3 acts as an autacoid to regulate NaCl absorption in the thick ascending limb. ATP induces NO production by NOS 3 in endothelial cells. We hypothesized that extracellular ATP activates NOS in thick ascending limbs through P2 receptors. To test this, we measured intracellular NO production using the NO-selective fluorescent dye DAF-2 in suspensions of rat medulla...

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ژورنال

عنوان ژورنال: Hypertension

سال: 2005

ISSN: 0194-911X,1524-4563

DOI: 10.1161/01.hyp.0000197954.93874.ef